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All Pericardial Mesothelioma Information FAQ
What is pericardial mesothelioma?
Pericardial mesothelioma is a serious heart condition which
consists of cancerous cells building up on the lining of the
heart. Similarly to pleural and peritoneal mesothelioma, this is
a terminal illness...
Asbestos Related Diseases
Asbestos is used in over 3000 modern products and most people have suffered at least some degree of exposure to it at one point or another. Most asbestos exposure is limited to minute portions of well maintained building materials such as concrete,...
Catching a Killer - New Steps Taken in Treating Mesothelioma
There’s a silent killer out there. It creeps up on its victims, attacks them quietly and unsuspectingly, and initiates a wound that develops over many years before it eventually causes pain. This unstoppable murderer is known as mesothelioma. ...
Causes of Mesothelioma
Mesothelioma is a rare type of cancer in the general
population. However, in individuals that were exposed to
asbestos, it is not as rare. That's because the only known,
established cause of Mesothelioma is asbestos. There are experts
that have...
The Signs And Symptoms Of Asbestosis - What To Look Out For
Asbestosis is a disease caused by exposure to high levels to asbestos, a dangerous mineral that can also result in mesothelioma, which is a deadly cancer. It is important for anyone that works or has worked with asbestos – and those that think they...
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Sarcomatoid Mesothelioma: A Deadly Curse Of Asbestos
Sarcomatoid Mesothelioma is a quite uncommon type of cancer caused due to asbestos exposure. While it is difficult to diagnose Sarcomatoid Mesothelioma, it hardly responds to any type of therapy. This is the most serious of all asbestos-related diseases. The possibility of finding this type of cancer is on the lips and the larynx. However, in certain cases it may affect the oral cavity as well. Like all other forms of mesothelioma cancers, this cancer is a fatal disease and hardly responds to any method of treatment. Even though radiation therapy is recommended for the treatment of these cancerous tumors, but some of them may not be radiosensitive and may defy radiation for treatment.
Diagnosis of Sarcomatoid Mesothelioma:
The differentiation of sarcomatoid mesothelioma from other cell tumors by light microscopy is quite difficult. The role of immunohistochemistry is also not well defined in its diagnosis. Since sarcomatoid mesothelioma is not always cytokeratin-negative, the distinction between it and sarcoma is not always possible. In this context, the doctors undertook a study to investigate the utility of diagnostic immunohistochemistry for distinguishing sarcomatoid mesothelioma from its histological mimics, high-grade sarcoma and pulmonary sarcomatoid carcinoma.
For its study, the researchers stained the mesotheliomas with sarcomatoid components. They assessed the intensity and
distribution of staining with the help of a semi quantitative scale. Only tumors with unequivocal staining were considered positive for tabulation. Then they compared the immunophenotypic profiles of these tumors with 24 high-grade sarcomas. The sarcomatoid carcinomas were also stained for thyroid transcription factor-1 (TTF-1).
The study showed that Cytokeratin 5/6 stained most of the epithelioids but the sarcomatoids were rarely stained. On the other hand, Calretinin and thrombomodulin each stained 70% of sarcomatoid. All 10 sarcomatoids were negative for TTF-1. This led to the conclusion that a wide immunophenotypic overlap exists among different sarcomatoids. Cytokeratin and calretinin have the most value in differentiating different sarcomatoids. Clinicopathological data, especially information about the gross appearance of the tumor is quite important for sarcomatoid tumors. Thus, it should be noted and carefully correlated with microscopic and immunohistochemical findings.
About the Author: Kirsten Hawkins is a asbestos and mesothelioma specialist from Nashville, TN. Visit http://www.asbestosblog.org/ for information on asbestos reform, mesothelioma lawsuit news, and more.
Source: www.isnare.com
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