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Asbestos: Every Day Jobs That Put You At Risk
People are affected by asbestos when they breathe the micro
fibers. These fibers can have long term affects to your health.
There have been many cases of people coming down with
Mesothelioma 20 and 30 years after being exposed to asbestos.
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Asbestos Mesothelioma- A Deadly Disease
Asbestos- the Main Culprit behind Asbestos Mesothelioma
Asbestos mesothelioma is a rare but dangerous cancer caused by exposure to asbestos particles suspended in the air. Asbestos is a group of naturally occurring silicate...
Asbestos Settlement- The Grim Reality
Reasons for Asbestos Settlement
In the recent years, there has been a drastic increase in the number of asbestos settlement cases, owing to the increasing number of people suffering from asbestos related diseases. Studies reveal that a majority of...
Mesothelioma Research: Search For Hope
Mesothelioma research refers to the studies for discovering new facts or information about mesothelioma cancers. Mesothelioma is a life threatening cancerous disease. It affects the lining of abdominal organs and lungs. Only known reason of this...
The dangers of asbestos
If you read the newspaper or watch the nightly news, chances are you've heard about some of the dangers of asbestos. What is often ignored in these messages, however, is that asbestos also has a number of useful properties. If used responsibly and...
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Sarcomatoid Mesothelioma: A Deadly Curse Of Asbestos
Sarcomatoid Mesothelioma is a quite uncommon type of cancer caused due to asbestos exposure. While it is difficult to diagnose Sarcomatoid Mesothelioma, it hardly responds to any type of therapy. This is the most serious of all asbestos-related diseases. The possibility of finding this type of cancer is on the lips and the larynx. However, in certain cases it may affect the oral cavity as well. Like all other forms of mesothelioma cancers, this cancer is a fatal disease and hardly responds to any method of treatment. Even though radiation therapy is recommended for the treatment of these cancerous tumors, but some of them may not be radiosensitive and may defy radiation for treatment.
Diagnosis of Sarcomatoid Mesothelioma:
The differentiation of sarcomatoid mesothelioma from other cell tumors by light microscopy is quite difficult. The role of immunohistochemistry is also not well defined in its diagnosis. Since sarcomatoid mesothelioma is not always cytokeratin-negative, the distinction between it and sarcoma is not always possible. In this context, the doctors undertook a study to investigate the utility of diagnostic immunohistochemistry for distinguishing sarcomatoid mesothelioma from its histological mimics, high-grade sarcoma and pulmonary sarcomatoid carcinoma.
For its study, the researchers stained the mesotheliomas with sarcomatoid components. They assessed the intensity and
distribution of staining with the help of a semi quantitative scale. Only tumors with unequivocal staining were considered positive for tabulation. Then they compared the immunophenotypic profiles of these tumors with 24 high-grade sarcomas. The sarcomatoid carcinomas were also stained for thyroid transcription factor-1 (TTF-1).
The study showed that Cytokeratin 5/6 stained most of the epithelioids but the sarcomatoids were rarely stained. On the other hand, Calretinin and thrombomodulin each stained 70% of sarcomatoid. All 10 sarcomatoids were negative for TTF-1. This led to the conclusion that a wide immunophenotypic overlap exists among different sarcomatoids. Cytokeratin and calretinin have the most value in differentiating different sarcomatoids. Clinicopathological data, especially information about the gross appearance of the tumor is quite important for sarcomatoid tumors. Thus, it should be noted and carefully correlated with microscopic and immunohistochemical findings.
About the Author: Kirsten Hawkins is a asbestos and mesothelioma specialist from Nashville, TN. Visit http://www.asbestosblog.org/ for information on asbestos reform, mesothelioma lawsuit news, and more.
Source: www.isnare.com
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